C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/17 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C12N 15/00 (2006.01) C12N 15/03 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2359853
Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
La présente invention concerne des polypeptides de chimiokine Bêta-10 humaine et l'ADN (ARN) codant pour lesdits polypeptides, ainsi qu'une méthode permettant de produire ces polypeptides à l'aide de techniques de recombinaison. L'invention concerne également des méthodes d'utilisation de ces polypeptides de chimiokine dans le traitement de la leucémie, des infections chroniques, des maladies auto-immunes, des troubles de type fibrose, du psoriasis et dans la cicatrisation de lésions. L'invention concerne en outre des antagonistes dirigés contre lesdits polypeptides de chimiokine, ainsi que leur utilisation thérapeutique dans le traitement de la polyarthrite rhumatoïde, des maladies auto-immunes et des maladies inflammatoires et infectieuses chroniques, des réactions allergiques, de la fièvre indépendante des prostaglandines et de l'insuffisance médullaire.
Adams Mark D.
Alderson Ralph
Appelbaum Edward R.
Gentz Solange H.l.
Li Haodong
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
Smithkline Beecham Corporation
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