Non-nucleoside reverse transcriptase inhibitors

Details Non-nucleoside reverse transcriptase inhibitors Non-nucleoside reverse transcriptase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 249/12 (2006.01) A61K 31/4196 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2682637

Compounds of formula (I), wherein R1, R2, R3, R4, R5, X, Y, and Ar are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

L'invention porte sur des composés de formule (I), dans laquelle R1, R2, R3, R4, R5, X, Y, et Ar sont tels que définis présentement ou sur des sels pharmaceutiquement acceptables de ces composés, qui inhibent la transcriptase inverse du VIH-1 et fournissent un procédé pour la prévention et le traitement d'infections par le VIH-1, et le traitement du SIDA et/ou du syndrome associé du SIDA. La présente invention porte également sur des compositions contenant des composés de formule (I) utiles pour la prévention et le traitement d'infections par le VIH-1 et le traitement du SIDA et/ou du syndrome associé au SIDA.

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