Novel calcitonin derivatives

Details Novel calcitonin derivatives Novel calcitonin derivatives

C - Chemistry, Metallurgy

07

K

C07K 14/585 (2006.01)

Patent

CA 2190633

Novel calcitonin derivatives represented by general formula (I) of pharmacologically acceptable salts thereof, wherein Z represents Gly or Cys; Xs are the same or different and each represents an .alpha.-amino acid residue; Y represents natural calcitonin, a natural calcitonin partial peptide or a natural calcitonin-analogous peptide residue; m is an integer of 5 to 8; and n is an integer of 0 to 3, provided that when m is 5, then the sequence of four residues on the C-terminal side of -(X)m- differs from the sequence of the residues at the 3- to 6-positions of natural calcitonin.

Nouveaux dérivés de calcitonine représentés par la formule générale (I) et sels pharmaceutiquement acceptables de ces dérivés. Dans cette formule, Z représente Gly ou Cys; les X sont identiques ou différents et représentent chacun un reste d' .alpha.-amino-acide; Y représente la calcitonine naturelle, un peptide partiel de calcitonine naturelle ou un reste peptidique analogue à la calcitonine naturelle; m est un entier de 5 à 8; et n est un entier de 0 à 3, sous réserve que, lorsque m correspond à 5, la séquence de 4 restes sur le côté C-terminal de (X)¿m?- diffère de la séquence des restes aux positions 3 à 6 de la calcitonine naturelle.

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