Use of thiopeptolides for determining the activity of adamts...

Details Use of thiopeptolides for determining the activity of adamts... Use of thiopeptolides for determining the activity of adamts...

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2597862

The invention concerns the use of thiopeptolides of formula R-(Xaa)n-Pro-X-Gly- S-Y-Z-Gly-(Xaa)m-R1 (I) as substrate for determining the activity of ADAMTS proteases, and a method for finding an ADAMTS protease modulator, more particularly an inhibitor.

La présente invention concerne l'utilisation de thiopeptolides de formule R-(Xaa)n-Pro-X-Gly-S-Y-Z-Gly-(Xaa)m-R1 (I) comme substrat pour détecter l'activité de protéases ADAM-TS, ainsi qu'un procédé pour détecter un modulateur de protéase ADAM-TS, en particulier un inhibiteur.

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