C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 303/40 (2006.01) C07C 311/29 (2006.01) C07D 309/14 (2006.01) C07D 493/06 (2006.01) C07D 493/08 (2006.01)
Patent
CA 2327498
The present invention relates to a process for the preparation of compounds of formula (b), in which a compound of formula (V) is reacted with a compound of formula (VI). The resulting compound of formula (IV) is reduced to a compound of formula (III) which is hydrolysed to a compound of formula (b). Alternatively, a compound of formula (IV) is hydrolysed to a compound of formula (a) which is reduced to a compound of formula (b). Compounds of formula (IV) are novel. In the formulae the variables are as defined in the claims. Compounds of formula (b) are useful as intermediates in the preparation of matrix metalloproteinase inhibitors.
L'invention concerne un procédé qui permet de préparer des composés de formule (b), dans lequel on fait réagir un composé de formule (V) avec un composé de formule (VI). Le composé obtenu, de formule (IV), est réduit en un composé de formule (III), qui est ensuite hydrolysé en un composé de formule (b). On peut également hydrolyser un composé de formule (IV) en un composé de formule (a), qui est ensuite réduit en un composé de formule (b). Les composés de formule (IV) sont nouveaux. Dans les formules, les variables sont telles que définies dans les revendications. Les composés de formule (b) sont utiles comme intermédiaires dans la préparation d'inhibiteurs des métalloprotéases de matrice.
Andresen Brian Michael
Hammen Philip Dietrich
Hawkins Joel Michael
Pfizer Products Inc.
Smart & Biggar
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