Peptide sequence for modulation of delta protein kinase c

Details Peptide sequence for modulation of delta protein kinase c Peptide sequence for modulation of delta protein kinase c

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61P 9/10 (2006.01) C07K 14/47 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2575123

A peptide identified from the annexin V protein sequence and having the ability to modulate the activity of delta protein kinase C (PKC) is described. The peptide and variants thereof bind to delta PKC and are effective to regulate delta PKC mediated cellular responses. In particular the annexin V peptide is able to inhibit protein-protein interaction with delta PKC, blocking intracellular translocation of delta PKC. Inhibition of delta PKC translocation confers protection to tissue at risk of exposure to ischemia or hypoxia or to reperfusion injury.

L'invention concerne un peptide identifié à partir de la séquence protéique d'annexine V et possédant la capacité de moduler l'activité de la protéine kinase C delta (PKC). Ce peptide et des variants de celui-ci se lient à PKC delta et sont efficaces pour réguler des réponses cellulaires à médiation par PKC delta. Plus spécifiquement, le peptide d'annexine V est capable d'inhiber l'interaction protéine-protéine avec PKC delta, bloquant la translocation intracellulaire de PKC delta. L'inhibition de la translocation de PKC delta confère une protection à un tissu risquant d'être exposé à l'ischémie ou à l'hypoxie ou à une lésion de reperfusion.

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