Substituted imidazoles having cytokine inhibitory activity

Details Substituted imidazoles having cytokine inhibitory activity Substituted imidazoles having cytokine inhibitory activity

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2257200

Compounds represented by formula (I) are disclosed. AR represents an aromatic group containing 6-10 atoms; and (a) represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 O or S atom. A pharmaceutical composition is also included. Methods of treating cancer and cytokine mediated diseases are also included.

L'invention concerne des composés représentés par la formule (I). Dans la formule, AR représente un groupe aromatique de 6 à 10 atomes; (a) représente un hétérocycle non aromatique à 4 ou 10 éléments comprenant au moins un atome de N et, facultativement, un ou deux atomes supplémentaires de N et 0 ou 1 atome de O ou S. On décrit par ailleurs une composition pharmaceutique et des procédés pour le traitement du cancer et des maladies à médiation cytokinique.

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