Pyridyl piperazines for the treatment of cns disorders

Details Pyridyl piperazines for the treatment of cns disorders Pyridyl piperazines for the treatment of cns disorders

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4439 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2571443

This invention is directed to compounds of Formula (I) and to pharmaceutical compositions comprising the compound of Formula (I) or a prodrug thereof and a pharmaceutically effective carrier. where G is G 1 or G2; where the dashed line represents an optional double bond; and where n is 1 or 2, and Ar1, Ar2, ... and Z are as defined in the specification. The invention is also directed to a method of treating or preventing in mammals, including humans, a disorder or condition that can be treated by altering serotonin-mediated neurotransmission, including a disorder selected from the group consisting of migraine, headache, cluster headache, anxiety, depression, dysthymia, major depressive disorder, migraine, post-traumatic stress disorder, avoidant personality disorder, borderline personality disorder and phobias This invention is also directed to intermediates useful in the synthesis of compounds of Formula (I).

L'invention concerne des composés de formule (I) ainsi que des compositions pharmaceutiques qui contiennent le composé de formule (I), ou un médicament de celui-ci, ainsi qu'un excipient pharmaceutiquement efficace. Dans cette formule, G représente G 1 ou G2; la ligne pointillée représente une liaison double facultative; n est égal à 1 ou 2; et Ar1, Ar2, ... et Z étant tels que définis dans le descriptif. Par ailleurs, l'invention concerne un procédé de traitement et de prévention chez les mammifères, y compris les humains, d'un trouble ou d'un état pathologique qui peut être traité par modification de la neurotransmission régulée par la sérotonine, notamment un trouble sélectionné dans le groupe qui comprend la migraine, la céphalée, la céphalée vasculaire de Horton, l'anxiété, la dépression, la dysthymie, le trouble dépressif majeur, le syndrome de stress post-traumatique, le trouble de la personnalité évitante, le trouble de la personnalité limite ainsi que les phobies. De plus, l'invention concerne des intermédiaires utilisés dans la synthèse du composé de formule (I).

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