A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) C07H 15/26 (2006.01) C08B 37/00 (2006.01) C09B 23/08 (2006.01) C09B 56/16 (2006.01) G01N 33/52 (2006.01) G01N 33/533 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2272320
The invention relates to compounds of formula (I): Fm(-A1) (-Bn) (-WO) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600 - 1200 nm; A is a .beta.-amyloid plaque binding biomolecule; B is a .beta.- amyloid plaque binding colorant; and W is a .beta.-amyloid plaque binding hydrophilic low-molecular structural element. The invention also describes the use of these compounds in in vivo and in vitro diagnosis of neurodegenerative diseases such as Alzheimer's disease by means of near infra-red radiation (NIR radiation) as a contrasting agent in fluorescence and transillumination diagnosis in the NIR range. Diagnostic agents containing said components are also disclosed.
L'invention concerne des composés de formule générale (I): F¿m?(-A¿1?) (-B¿n?) (-W¿o?), dans laquelle F est une molécule signal de colorant présentant au moins une valeur d'absorption maximale comprise entre 600 et 1200 nm; A est une biomolécule se fixant sur les plaques de .beta.-amyloïde; B est un colorant se fixant sur les plaques de .beta.-amyloïde; W est un élément structural de faible poids moléculaire, hydrophile, se fixant sur les plaques de .beta.-amyloïde. L'invention concerne également l'utilisation de ces composés pour le diagnostic in vivo et in vitro de maladies neurodégénératives, telles que la maladie d'Alzheimer, au moyen d'un rayonnement infrarouge proche servant d'agent de contraste dans le diagnostic par fluorescence et transillumination dans le domaine de l'infrarouge proche. L'invention concerne enfin des agents de diagnostic contenant lesdits composés.
Dyrks Thomas
Licha Kai
Riefke Bjorn
Semmler Wolfhard
Turner Jonathan
Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat
Marks & Clerk
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