Phenyl derivatives as ppar agonists

Details Phenyl derivatives as ppar agonists Phenyl derivatives as ppar agonists

C - Chemistry, Metallurgy

07

D

C07D 213/38 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61P 3/10 (2006.01) C07D 213/30 (2006.01) C07D 213/32 (2006.01) C07D 213/56 (2006.01) C07D 213/82 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 239/28 (2006.01) C07D 241/12 (2006.01)

Patent

CA 2543249

This invention relates to compounds of Formula (I) wherein one of R5, R6 and R7 is (Formula II), and X1, X2, Y1 to Y4, R1 to R13 and m and n are as defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR.delta. and/or PPAR.alpha. agonists.

Cette invention concerne des composés de formule (I), dans laquelle R?5¿, R?6¿ et R?7¿ sont représentés par la formule (II) et X?1¿, X?2¿, Y?1¿ à Y?4¿, R?1¿ à R?13¿ et m et n sont tels que définis dans le mémorandum descriptif. Elle concerne tous les énantiomères et les sels pharmaceutiquement acceptables et esters desdits composés. L'invention concerne en outre des compositions pharmaceutiques contenant ces composés, leur méthode de préparation et leur utilisation pour le traitement et/ou la prévention de maladies modulées par les agonistes PPAR? et/ou PPAR?.

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