Method for detecting chromosomal abnormalities

Details Method for detecting chromosomal abnormalities Method for detecting chromosomal abnormalities

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2731969

The invention relates to an in vitro method for detecting chromosomal abnormalities in a mammal, including the in situ hybridization of n chromosomes from a metaphase chromosome preparation with sets having a plurality of nucleic acids, each set being hybridized, over a length of 700,000 to 3,000,000 contiguous bp, in a manner specific to the subtelomeric ends specific to said chromosomes, each set being detectably marked by a fluorochrome such that each chromosome is distinguishable by a particular fluorochrome or a particular fluorochrome combination.

L'invention concerne un procédé in vitro pour détecter des anomalies chromosomiques chez un mammifère, comprenant l'hybridation in situ de n chromosomes d'une préparation de chromosomes métaphasiques avec des ensembles d'une pluralité d'acides nucléiques, chaque ensemble s'hybridant, sur une longueur de 700 000 à 3 000 000 pb contiguës, de manière spécifique aux extrémités subtélomériques spécifiques desdits chromosomes, chaque ensemble étant marqué de manière détectable par un fluorochrome, de telle sorte que chaque chromosome est distinguable par un fluorochrome particulier ou une combinaison particulière de fluorochromes.

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