Indole derivatives as crth2 receptor antagonists

Details Indole derivatives as crth2 receptor antagonists Indole derivatives as crth2 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01)

Patent

CA 2737460

The compound (+) {7R-[[(4- fluorophenyl)sulfonyl] (methyl)ammo]-6,7,8,9- tetrahydropyrido [1,2-a]mdol-10-yl}acetic acid and pharmaceutically acceptable salts thereof are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-meidated diseases such as asthma.

La présente invention concerne le composé qu'est l'acide (+) {7R-[[(4-fluorophényl)sulfonyl](méthyl)ammo]-6,7,8,9-tétrahydropyrido[1,2-a]mdol-10-yl}acétique et ses sels pharmaceutiquement acceptables, qui sont des antagonistes du récepteur à la PGD2, CRTH2, et qui, en tant que tels, se révèlent utiles dans le cadre du traitement et/ou de la prévention des maladies à médiation par CRTH2, comme l'asthme.

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