Pseudomonas exotoxin a cd4+ t-cell epitopes

Details Pseudomonas exotoxin a cd4+ t-cell epitopes Pseudomonas exotoxin a cd4+ t-cell epitopes

C - Chemistry, Metallurgy

07

K

C07K 14/21 (2006.01) A61K 47/48 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2622525

The present invention provides PE CD4+ T-cell epitopes, as well as novel variants that exhibit reduced immunogenic responses, as compared to the parental PE. The present invention further provides DNA molecules that encode novel PE variants, host cells comprising DNA encoding novel PE variants, as well as methods for making PEs less immunogenic. In addition, the present invention provides various compositions that comprise these PE variants that are less immunogenic than wild-type PEs.

La présente invention concerne des épitopes de cellules T CD4+ PE, de même que des variantes innovantes qui présentent des réponses immunogènes réduites par rapport à celles des PE parentaux. La présente invention concerne en outre des molécules d'ADN qui codent pour des variantes innovantes des PE, des cellules hôtes comprenant l'ADN qui code pour des variantes innovantes des PE, de même que des procédés permettant de rendre les PE moins immunogènes. De plus, La présente invention concerne diverses compositions qui comprennent ces variantes de PE moins immunogènes que les PE de type sauvage.

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