Hmgi proteins in tumors and obesity

Details Hmgi proteins in tumors and obesity Hmgi proteins in tumors and obesity

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/40 (2006.01) A61K 31/495 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2259635

The invention pertains to HMGI genes and proteins, specifically to HMGI-C and HMGI-Y genes and proteins; and the use of these products in various methods. The invention further relates to methods of treating obesity and tumors by reducing the activity of HMGI genes; to methods of making non-human transgenic mammals; to methods of screening for HMGI inhibitors; and to methods of detecting for protein and antibodies to HMGI genes.

L'invention porte sur des gènes et des protéines HMGI, notamment sur des gènes et des protéines HMGI-C et HMGI-Y, et sur l'utilisation de ces produits dans divers procédés. L'invention porte également sur des procédés de traitement de l'obésité et de tumeurs qui consistent à réduire l'activité des gènes HMGI; sur des procédés de production de mammifères transgéniques; sur des procédés de criblage d'inhibiteurs HMGI et sur des procédés de détection de protéines et d'anticorps contre les gènes HMGI.

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