Method of diagnosing transmissible spongiform encephalopathies

Details Method of diagnosing transmissible spongiform encephalopathies Method of diagnosing transmissible spongiform encephalopathies

G - Physics

01

N

G01N 33/68 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2367696

The invention relates to a method of pre-clinical and clinical diagnosis of transmissible spongiform encephalopathies, characterised in that the altered expression of a marker protein is measured. In particular embodiments, in the method according to the invention, the marker protein measured is the prion protein PrP-sen or interferon gamma (IFN.gamma.), or the laminin receptor (LR) or the laminin receptor precursor (LRP). The invention also relates to a test kit using antibodies specific to the marker protein according to the invention. The invention further relates to a test kit using oligonucleotides which are capable of hybridising under stringent conditions with the nucleic acid coding for the marker protein according to the invention. The invention further relates to the use of antibodies or oligonucleotides which are specific for the above-mentioned marker proteins in a method according to the invention. The invention further relates to the use of the test kit for diagnosing transmissible spongiform encephalopathies.

L'invention concerne un diagnostic clinique et préclinique des encéphalopathies spongiformes transmissibles, caractérisés par la mesure de l'expression modifiée d'une protéine de marquage. Dans des modes de réalisation particuliers, selon la méthode de l'invention, la protéine de marquage mesurée et la protéine prion PrP-sen ou interféron gamma (IFN.gamma.), ou le récepteur de la laminine (LR) ou le précurseur du récepteur de la laminine (LRP). L'invention porte également sur des trousses d'analyse utilisant des anticorps spécifiques à la protéine de marquage de l'invention. L'invention concerne en outre une trousse d'analyse utilisant des oligonucléotides pouvant s'hybrider dans des conditions strictes avec l'acide nucléique codant pour la protéine de marquage de l'invention. L'invention concerne également l'utilisation, dans un méthode de l'invention, d'anticorps ou d'oligonucléotides spécifiques aux protéines de marquage susmentionnées. L'invention concerne enfin l'utilisation de la trousse d'analyse pour le diagnostic d'encéphalopathies spongiformes transmissibles.

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