Compositions for preventing, reducing or treating...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61P 17/02 (2006.01) A61P 17/04 (2006.01)

Patent

CA 2589670

The present invention relates to the field of epidermal repair. More particularly, the invention concerns the use of a molecule able to inhibit a heteromeric receptor comprising OSMR.beta. as a subunit, for the preparation of a composition for inhibiting the expression of inflammatory factors by the keratinocytes. In particular, the invention concerns the use of antagonists and/or expression inhibitors of OSM, IL-17, TNF.alpha., IL-31, IFN-.gamma., and/or the OSMR.beta. subunit, for the preparation of cosmetic or dermatologic compositions, especially for treating inflammatory skin diseases. Methods for obtaining in vitro or animal models of skin inflammation diseases are also disclosed. These models can be used for screening molecules to find new drugs to prevent or treat psoriasis and other dermatitis.

La présente invention se rapporte au domaine de la réparation épidermique. L'invention concerne plus particulièrement l'utilisation d'une molécule apte à inhiber un récepteur hétéromère comprenant OSMR.beta. comme sous-unité pour la préparation d'une composition permettant d'inhiber l'expression de facteurs inflammatoires au moyen des kératinocytes. L'invention concerne en particulier l'utilisation d'antagonistes et/ou d'inhibiteurs d'expression de OSM, IL-17, TNFa, IL-31, IFN-.gamma., et/ou la sous-unité OSMR.beta. en vue de la préparation de compositions cosmétiques ou dermatologiques, notamment pour le traitement de maladies cutanées inflammatoires. L'invention concerne en outre des procédés d'obtentionin vitro ou de modèles animaux de maladies inflammatoires cutanées. Ces modèles peuvent être utilisés pour dépister des molécules afin de trouver de nouveaux médicaments de prévention ou de traitement du psoriasis et d'autres dermatites.

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