Indole-substituted 3-cyanopyridines as kinase inhibitors

Details Indole-substituted 3-cyanopyridines as kinase inhibitors Indole-substituted 3-cyanopyridines as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/465 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2709288

Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X is -O-, -N(R3)-, -S-,-S(O)-or-S(O)2-;R2 is a C1-4 alkyl group or -CF3; and R1, R3, R4 and p are as defined herein; wherein the compounds are useful as kinase inhibitors. Also disclosed are pharmaceutical compositions containing, and intermediate compounds and methods for making the compounds of formula (I) and their pharmaceutically acceptable salts; and methods of using the foregoing to treat inflammatory and autoimmune diseases such as asthma, colitis, multiple sclerosis, psoriasis, arthritis, rheumatoid arthritis, inflammatory bowel disease, and joint inflammation.

L'invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, où X est -O-, -N(R3)-, -S-, -S(O)- ou -S(O)2-; R2 est un groupe alkyle en C1-4 ou -CF3; et R1, R3, R4 et p sont tels que définis ici. Ces composés sont utiles en tant qu'inhibiteurs de kinase. Sont également décrites des compositions pharmaceutiques les contenant, et des composés intermédiaires et des procédés de préparation des composés de formule et leurs sels pharmaceutiquement acceptables; et des procédés d'utilisation des éléments précédents pour traiter des maladies inflammatoires et auto-immunitaires telles que l'asthme, la colite, la sclérose en plaques, le psoriasis, l'arthrite, la polyarthrite rhumatoïde, une affection abdominale inflammatoire et une inflammation des articulations.

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