The regulation of systemic immune responses utilizing...

Details The regulation of systemic immune responses utilizing... The regulation of systemic immune responses utilizing...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/525 (2006.01) C07K 14/535 (2006.01) C07K 14/54 (2006.01) C07K 14/545 (2006.01) C07K 14/55 (2006.01) C07K 14/57 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2224097

A method of altering the specific, systemic immune response of an individual to a target antigen by the co-administration of a cytokine, an adhesion or accessory molecule, and the target antigen. The target antigen may be a tumor cell, a tumor cell antigen, an infectious agent or other foreign antigen, or other antigens to which an enhanced systemic immune response is desirable. Alternatively, the antigen may be a non-foreign antigen when a suppression of a systemic immune response is desired. The resulting systemic immune response is specific for the target antigen.

L'invention concerne un procédé permettant de modifier la réponse immune systémique spécifique d'une personne envers un antigène cible en lui administrant une cytokine, une molécule accessoire ou d'adhésion, et l'antigène cible. L'antigène cible peut être une cellule tumorale, un antigène de cellule tumorale, un agent infectieux ou un autre antigène étranger, ou d'autres antigènes auxquels une réponse immune systémique améliorée est souhaitable. Dans une variante, l'antigène peut être un antigène non étranger lorsqu'une suppression de la réponse immune systémique est souhaitée. La réponse immune systémique obtenue est spécifique à l'antigène cible.

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