Method of intracellular binding of target molecules

Details Method of intracellular binding of target molecules Method of intracellular binding of target molecules

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/70 (2006.01) C07K 16/00 (2006.01) C07K 16/10 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2137558

2137558 9402610 PCTABS00030 The present invention relates to a method by which one can target an undesired target molecule or target antigen, preferably a protein. The method comprises the intracellular expression of an antibody capable of binding to the target. A DNA sequence is delivered to a cell, the DNA sequence contains a sufficient number of nucleotides coding for the portion of an antibody capable of binding to the target operably linked to a promoter that will permit expression of the antibody in the cell(s) of interest. The antibody is then expressed intracellularly and binds to the target, thereby disrupting the target from its normal actions.

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