Polyaminated ligands and metal complexes thereof

Details Polyaminated ligands and metal complexes thereof Polyaminated ligands and metal complexes thereof

C - Chemistry, Metallurgy

07

D

C07D 257/02 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) C07C 229/16 (2006.01) C07D 403/14 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2139374

Poly(amino acid) derivatives, which are chelating agents of paramagnetic metal ions, in which at least 3 of the donor nitrogen atoms carry identical or different substituents, of formula CH (R1) - X , in which X represents CO2R a, CONR b R c or P(R d)O2H and R a, R b and R c, which are identical or different, represent H or optionally hydroxylated (C1-C8)alkyl, R d represents OH, (C1-C8)alkyl or (C1-C8)alkoxy and R1 represents a hydro-philic group with a molecular weight greater than 200 containing at least 3 oxygen atoms, with the proviso that at least 3 of the X groups are optionally salified acid functional groups.

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