Method for producing medicaments from plant extracts, in a...

Details Method for producing medicaments from plant extracts, in a... Method for producing medicaments from plant extracts, in a...

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 35/78 (2000.01)

Patent

CA 2352542

A dry extract is reduced in volume by compacting to produce a solid form of pharmaceutical such as a tablet or capsule containing plant extracts. The particles of compacted matter are subsequently screened to a uniform grain size, masked with titanium dioxide, talc, and highly dispersed silicon dioxide in a first mixing process, and treated with additional adjuvants in two more mixing steps. The masked compacted matter has the flowability required for making tablets and is protected against moisture absorption. The extract portion is a minimum of 65 percent by weight, which allows for producing relatively small tablets that have low disintegration times due to masking.

Pour la production de médicaments contenant des extraits végétaux sous forme de comprimés ou de capsules, on commence par compacter un extrait sec pour obtenir une réduction de volume. Ensuite, les particules du produit compacté, triées par tamisage à une granulométrie uniforme, sont masquées dans une opération de mélange avec du dioxyde de titane, de talc et de dioxyde de silicium microdipersé puis, dans deux autres étages de mélange, sont traitées par des agents auxiliaires supplémentaires. Le produit compacté masqué a les propriétés d'écoulement nécessaires à la production de comprimés et est protégé des influences de l'humidité. La fraction d'extrait s'élève à au moins 65 % en poids, de telle façon que l'on puisse produire des comprimés comparativement petits avec de faibles temps de désagrégation en raison du masquage.

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