Bicyclic antagonists selective for the .alpha.v.beta.3 integrin

A - Human Necessities – 61 – K

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A61K 31/195 (2006.01) A61K 31/4704 (2006.01) A61P 19/10 (2006.01) C07D 215/22 (2006.01) C07D 215/227 (2006.01) C07D 239/14 (2006.01)

Patent

CA 2378860

This invention provides novel bicyclic compounds of Formula (I): wherein u, v, m, Y, G, A-B, R1, R1a, R2, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption and compounds of Formula (II) wherein u, v, m, Y, G, D, A-B, R1, R1a, R2, R3, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption.

La présente invention concerne de nouveaux composés bicycliques de formule (I): dans laquelle u, v, m, Y, G, A-B, R?1¿, R?1a¿, R?2¿, R?4¿, R?5a¿, et R?5b¿ sont tels que définis dans le descriptif, ces composés possédant une activité en tant qu'inhibiteurs de la résorption osseuse et des composés de formule (II) dans laquelle u, v, m, Y, G, D, A-B, R?1¿, R?1a¿, R?2¿, R?3¿, R?4¿, R?5¿, R?5a¿, et R?5b¿ sont tels que définis dans le descriptif, ces composés présentant une activité en tant qu'inhibiteurs de la résorption osseuse.

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