Stabilised supersaturated solids of lipophilic drugs

Details Stabilised supersaturated solids of lipophilic drugs Stabilised supersaturated solids of lipophilic drugs

A - Human Necessities

61

K

A61K 9/14 (2006.01)

Patent

CA 2558582

The present invention relates to a pharmaceutical composition with improved dissolution of lipophilic drugs in an aqueous medium. It is found that pharmaceutical compositions comprising a powder of lipophilic compounds, such as hormones and steroids (e.g. drospirenone and estradiol valerate), on molecularly dispersed form together with a carrier having a specific surface area of at least 250 m2/g, such as silica dioxide, e.g. silica dioxide marketed under the name Aeroperl®, has improved dissolution properties of the lipophilic drug.

La présente invention concerne une composition pharmaceutique permettant d'obtenir une dissolution améliorée de médicaments lipophiles dans un milieu aqueux. On a découvert que les compositions pharmaceutiques comprenant une poudre de composés lipophiles, et notamment des hormones et des stéroïdes (par ex., la drospirénone et l'estradiol valérate), sous forme moléculairement dispersée conjointement avec un support présentant une surface spécifique d'au moins 250 m?2¿/g, tel que le dioxyde de silice, et notamment le dioxyde de silice commercialisé sous le nom d'Aeroperl®, présentent des propriétés de dissolution améliorées du médicament lipophile.

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