Treatment of iga1 deposition diseases

Details Treatment of iga1 deposition diseases Treatment of iga1 deposition diseases

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01)

Patent

CA 2558873

The present invention discloses the use of bacterial IgAl proteases to treat IgAl deposition in tissue and organs. Bacterial IgAl proteases specifically cleave IgAl molecules and thus provide a means to specifically cleave and remove IgAl depositions. Accordingly, therapeutic agents for the treatment of diseases characterized by IgA deposition are provided. In particular, therapeutic agents to treat IgA Nephropathy, Dermatitis herpetiformis (DH), and Henoch-Schoenlein purpura (HS) are disclosed.

L'invention porte sur l'utilisation de protéases bactériennes d'IgA1 pour traiter le dépôt d'IgA1 dans les tissus et les organes. Lesdites protéases coupent spécifiquement les molécules d'IgA1 et constituent donc un moyen d'en éliminer les dépôts, et des agents thérapeutiques de traitement de maladies dues à ces dépôts, et en particulier les néphropathies à IgA, les dermatites herpétiforme (DH) et la purpura de Henoch-Schoenlein (HS).

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