Novel method of the manufacture of suppositories

Details Novel method of the manufacture of suppositories Novel method of the manufacture of suppositories

A - Human Necessities

61

K

A61K 9/02 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2178220

The invention concerns the field of pharmaceutical technology and, in particular, a method for the manufacture of carbon-dioxide releasing laxative suppositories in which fatty substances are melted separately. Vegetable lecithine is added to the resulting fluid mass and then a mineral opacifier is incorporated. During stirring, potassium acid tartrate and sodium bicarbonate are added, both of these constituents having a specific particle size. The fluid suspension is continuously stirred until it becomes perfectly homogeneous, after which the fluid suspension is removed. The method of the invention is for the manufacture of shelf-stable effervescent suppositories.

L'invention se rapporte au domaine de la pharmacotechnie. Elle a plus précisément pour objet un procédé de réalisation de suppositoires dégageant du gaz carbonique, doués d'action laxative dans lequel les matières grasses sont mises à fondre séparément et dans la masse fluide résultant de la fusion on ajoute de la lécithine végétale puis on incorpore un agent opacifiant minéral, on verse ensuite, sous agitation, du tartrate acide de potassium et du bicarbonate de sodium, ces deux constituants présentant une granulométrie particulière puis on poursuit l'agitation jusqu'à parfaite homogénéité avant de procéder au soutirage de la suspension fluide. Application à la réalisation de suppositoires effervescents stables à la conservation.

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