Nucleic acids and corresponding proteins entitled 254p1d6b...

Details Nucleic acids and corresponding proteins entitled 254p1d6b... Nucleic acids and corresponding proteins entitled 254p1d6b...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 5/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2514058

A novel gene 254P1D6B and its encoded protein, and variants thereof, are described wherein 254P1D6B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 254P1D6B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 254P1D6B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 254P1D6B can be used in active or passive immunization.

L'invention porte sur un nouveau gène, le 254P1D6B et sur la protéine codée par lui, et sur ses variantes. Le 254P1D6B présente une expression spécifique de tissus dans des tissus adultes normaux, mais une expression aberrante dans les tissus des cancers répertoriés dans le tableau I. Le 254P1D6B est donc un outil de diagnostique, pronostique, prophylactique et/ou thérapeutique du cancer. Le 254P1D6B, ses fragments, la protéine codée par lui, ou leurs variantes, peuvent servir à provoquer une réponse immunitaire humorale ou cellulaire, et les anticorps ou cellules T réagissant au 254P1D6B peuvent produire une immunisation passive ou active.

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