Glycyrrhizin high-concentration preparation

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/704 (2006.01) A61K 31/198 (2006.01) A61P 1/16 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2534259

[PROBLEMS] To provide a glycyrrhizin/aminoacetic acid/cysteine combination drug containing an active ingredient in high concentration and excelling in stability and safety. [MEANS FOR SOLVING PROBLEMS] Stability at compounding of active ingredient in high concentration has been improved by avoiding the addition of sulfite salts having been used as a stabilizer in existing products. As glycyrrhizin high-concentration preparations, there is provided a drug composition comprising 8 to 16 mg/mL of glycyrrhizin, 3 to 6 mg/mL of cysteine and 80 to 160 mg/mL of aminoacetic acid wherein no sulfite salts are added as an additive.

Le but de cette invention est d'obtenir un médicament à combinaison glycyrrhizine/acide aminoacétique/cystéine contenant un ingrédient actif dans une concentration élevée et présentant une excellente stabilité et innocuité. Selon cette invention, on a amélioré la stabilité de malaxage de l'ingrédient actif en concentration élevée en évitant d'ajouter des sels de sulfite qui ont été utilisés comme agent de stabilisation dans des produits existants. Comme pour les préparations à concentration élevée en glycyrrhizine, la composition de médicament de l'invention comprend entre 8 et 16 mg/mL de glycyrrhizine, entre 3 et 6 mg/mL de cystéine, et entre 80 et 160 mg/mL d'acide aminoacétique, aucun sel de sulfite n'ayant été incorporé comme additif.

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