C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) C07D 211/00 (2006.01) C07D 233/00 (2006.01)
Patent
CA 2432959
The invention concerns novel sodium channel modulators derived from 2-piperidylimidazoles. The inventive compounds correspond to the general formula (I), wherein: R?1¿ represents a hydrogen atom or an -X-Y-R?4¿ radical wherein -X-Y represents a bond, a -CO-, -CO-O- -CO-NH- or -CS-NH- radical and R?4¿ represents an alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl radical, said radicals being optionally substituted; R?2¿ represents in particular an alkyl, cycloalkyl, cycloalkylalkyl or aryl radical optionally substituted; and R?3¿ represents a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, or aryl radical optionally substituted.
L'invention concerne de nouveaux modulateurs de canaux sodiques dérivés de 2- pipéridylimidazoles. Les composés de l'invention répondent à la formule générale (I) dans laquelle: R1 représente un atome d'hydrogène ou un radical - X-Y-R4 dans lequel -X-Y- représente une liaison, un radical -CO-, -CO-O-, -CO- NH- ou -CS-NH- et R4 représente un radical alkyle, haloalkyle, cycloalkyle, cycloalkylalkyle, aryle ou aralkyle, lesdits radicaux aralkyle ou aryle étant éventuellement substitués; R2 représente notamment un radical alkyle, cycloalkyle, cycloalkylalkyle ou aryle éventuellement substitué; et R3 représente un atome d'hydrogène ou un radical alkyle, cycloalkyle, cycloalkylalkyle, ou aryle éventuellement substitué.
Bigg Dennis
Liberatore Anne-Marie
Pommier Jacques
Goudreau Gage Dubuc
Ipsen Pharma S.a.s
Societe de Conseils de Recherches Et D'applications Scientifique
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