Anti-cd 30 antibodies preventing proteolytic cleavage and...

C - Chemistry – Metallurgy – 07 – K

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C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/46 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2210620

An antibody which binds to the CD30 antigen and a) releases sCD30 from Hodgkin's disease cells to an amount of, or less than, 10 %and b) does not bind to B cell non-Hodgkin's lymphomas or plasma cells to a considerable extent is useful for the treatment of Hodgkin's disease.

Anticorps qui se lie à l'antigène CD30 et qui (a) réduit la libération des CD30 solubles à partir des cellules de la maladie de Hodgkin à un niveau ne dépassant pas 10 %, et (b) ne présente pas un niveau de liaison élevé avec les cellules de plasma ou les lymphomes des lymphocytes B non associés à la maladie de Hodgkin. Cet anticorps convient au traitement de la maladie de Hodgkin.

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