Indan derivative and thromboxane antagonist containing the same

Details Indan derivative and thromboxane antagonist containing the same Indan derivative and thromboxane antagonist containing the same

C - Chemistry, Metallurgy

07

C

C07C 311/00 (2006.01) A61K 31/195 (2006.01) A61K 31/38 (2006.01) A61K 31/415 (2006.01) A61K 31/50 (2006.01) C07C 311/13 (2006.01) C07C 311/17 (2006.01) C07C 311/19 (2006.01) C07C 311/29 (2006.01) C07C 311/42 (2006.01) C07D 231/20 (2006.01) C07D 237/04 (2006.01) C07D 333/34 (2006.01)

Patent

CA 2105067

The present invention relates to indan derivatives represented by the formula (1) or pharmaceutically acceptable salts thereof: (See formula I) [wherein R1 represents C1 to C12 alkyl, benzyl, styryl, naphthyl, optionally substituted phenyl or optionally substituted thienyl; R2 represents carboxyl, C1 to C4 alkoxycarbonyl, (See formulas) Y represents -(CH2)p- (wherein p represents an integer of 0 to 5), -CO-(CH2)q~, -CH(OH)-(CH2)q~, (wherein q represents an integer of 1 to 4, and the symbol ~ represents a linkage to R2), oxymethylene or ethylene; and n represents an integer of 1 to 4]. The compounds according to the present invention potently antagonize the action of thromboxane A2, and therefore useful for the treatment and prevention of diseases caused by thromboxane A2 such as angiosis, vasospasm, asthma and the like.

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