C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 31/7052 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2354456
The present invention is directed to CTGF fragments comprising at least exon 4 or exon 5 of CTGF and having mitogenic activity. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the mitogenic activity of said CTGF fragments and to the compositions so identified.
La présente invention concerne des fragments du facteur de croissance du tissu conjonctif (CTGF), comprenant au moins l'exon 4 ou l'exon 5 du facteur de croissance du tissu conjonctif et ayant un activité mitogène. La présente invention concerne également des méthodes utilisant lesdits fragments CTGF pour identifier des compositions modulant l'activité mitogène desdits fragments CTGF, et les compositions ainsi identifiées.
Grotendorst Gary R.
Neff Thomas B.
Fibrogen Inc.
Mbm Intellectual Property Law Llp
University Of Miami
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