Intermediates for preparing glycogen phosphorylase inhibitors

Details Intermediates for preparing glycogen phosphorylase inhibitors Intermediates for preparing glycogen phosphorylase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 491/04 (2006.01) C07D 209/00 (2006.01) C07D 209/42 (2006.01) C07D 317/00 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2472205

The instant invention provides novel processes and intermediates useful in the preparation of certain N-(indole-2-carbonyl)-.beta.-alaninamide compounds, which compounds are glycogen phosphorylase inhibitors useful in the treatment of diseases such as hypercholesterolemia, hyperglycemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis, diabetes, diabetic cardiomyopathy, infection, tissue ischemia, myocardial ischemia, and in inhibiting tumor growth.

L'invention concerne de nouveaux procédés et intermédiaires utiles dans la préparation de certains composés N-(indole-2-carbonyl)-.beta.-alaninamide, ces composés étant des inhibiteurs de phosphorylase glycogène utiles dans le traitement de maladies telles que l'hypercholestérolémie, l'hyperglycémie, l'hyperinsulinémie, l'hyperlipidémie, l'hypertension, l'athérosclérose, le diabète, la cardiomyopathie diabétique, l'infection, l'ischémie tissulaire, l'ischémie myocardique, et permettant d'inhiber la croissance tumorale.

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