Hepoxilins and modulators of ichthyin for treatment skin...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/557 (2006.01) A61P 17/00 (2006.01) C07K 16/28 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2568780

The present application relates to compositions and methods for treating skin disorders, ,dry skin, and protection of skin in inflammatory events. The present application more particularly discloses the identification of new genes and metabolic pathways involved in skin disorders, which provide novel targets and approaches for treating said disorders and for screening biologically active compounds. The present invention also provides various products and constructs, such as probes, primers, vectors, recombinant cells, which can be used to implement the above methods. The invention may be used to detect or treat various skin disorders, particularly dry and inflammatory skin disorders, in various subjects, including mammalian subjects, particularly human beings.

L'invention concerne des compositions et des procédés pour traiter des troubles de la peau, la sécheresse cutanée, et la protection de la peau contre les inflammations. L'invention concerne, en particulier, l'identification de nouveaux gènes et de passages du métabolisme impliqués dans les troubles de la peau, qui produisent de nouvelles cibles et des approches pour traiter lesdits troubles et pour cribler des composés bioactifs. L'invention concerne également de nombreux produits et constructions, tels que des sondes, des amorces, des vecteurs, des cellules recombinées, qui peuvent être utilisés pour mettre en place de nouveaux procédés. L'invention peut être utilisée pour détecter ou traiter de nombreux troubles de la peau, en particulier des troubles de la sécheresse cutanée et des inflammations, chez de nombreux sujets, notamment chez les mammifères, en particulier les êtres humains.

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