Use of basic amino acids to solubilize immunoglobulins

Details Use of basic amino acids to solubilize immunoglobulins Use of basic amino acids to solubilize immunoglobulins

A - Human Necessities

61

K

167/139

A61K 39/00 (2006.01) A61K 47/18 (2006.01) C07K 14/73 (2006.01) C07K 16/00 (2006.01) C07K 16/06 (2006.01)

Patent

CA 2005119

Abstract A method to solubilize immunoglobulins to practical concentrations in aqueous media employs solubilizing preparations of basic amino acids and/or their salts. For example, histidine, lysine, and arginine and mixtures thereof, in effective concentrations are capable of enhancing the solubility of relatively in- soluble proteins and immunoglobulins in general, and in particular, of IgG, especially IgG3, and of T4.

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