C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 39/21 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/22 (2006.01) C12N 7/00 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2395269
Nucleic acid constructs containing HIV-1 GAG/POL and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified constructs and viral particles of the invention may be useful in gene therapy for numberous disorders, including HIV infection, or as a vaccine for HIV-1 immunotherapy and immunoprophylaxis.
Cette invention concerne des constructions d'acides nucléiques renfermant des gènes VIH-1 GAG/POl et VIS gag ou VIS env qui ont été mutés dans le but d'éliminer ou de réduire des séquences d'inhibition/instabilité. L'invention porte également sur des particules virales et sur des cellules hôtes renfermant ces constructions et/ou particules virales. Les constructions et particules virales en question peuvent convenir pour la thérapie génique de nombreux troubles, dont l'infection à VIH,, ou comme vaccin utilisé contre le VIH-1 à des fins thérapeutiques ou prophylaxiques.
Sim & Mcburney
The Government Of The United States Of America As Represented By
LandOfFree
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