Tissue kallikrein for the treatment of huntington's disease

Details Tissue kallikrein for the treatment of huntington's disease Tissue kallikrein for the treatment of huntington's disease

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2759490

This invention relates to methods of treating the prodrome and adult onset stage of Huntington's disease or symp-toms thereof, and or Juvenile Huntington's disease symptoms thereof. Methods of the invention include administering a therapeu-tically effective amount of tissue kallikrein, variants or active fragments thereof. The invention further relates to pharmaceutical compositions comprising a therapeutically effective amount of tissue kallikrein, variants or active fragments thereof formulated for oral or intranasal administration.

Cette invention porte sur des procédés de traitement du stade de prodrome et d'initiation adulte de la maladie de Huntington ou de symptômes de celle-ci, et/ou de la maladie de Huntington juvénile ou de symptômes de celle-ci. Les procédés de l'invention comprennent l'administration d'une quantité thérapeutique efficace de kallicréine tissulaire, de variants ou de fragments actifs de celle-ci. L'invention porte en outre sur des compositions pharmaceutiques comportant une quantité thérapeutique efficace de kallicréine tissulaire, de variants ou de fragments actifs de celle-ci formulés pour une administration orale ou intra-nasale.

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