Recombinant antibodies to human interkleukin-1 beta

Details Recombinant antibodies to human interkleukin-1 beta Recombinant antibodies to human interkleukin-1 beta

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01) C07K 16/24 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2396212

An IL-1.beta. binding molecule, in particular an antibody to human IL-1.beta., especially a human antibody to human IL-1.beta. is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteroporosis and other inflammatory arthritides.

L'invention concerne une molécule de liaison d'interleukine 1.beta., notamment un anticorps anti-interleukine 1.beta. humain, plus spécifiquement un anticorps humain anti-interleukine 1.beta., les régions hypervariables des chaînes légères et lourdes renfermant des séquences d'acides aminés comme défini. Cette molécule est utilisée dans le traitement d'une maladie ou d'un trouble à médiation par interleukine-1, par exemple, l'ostéo-arthrite, l'ostéoporose et autres types d'arthrite inflammatoire.

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