Substituted pyrrole derivatives as hmg-coa reductase inhibitors

Details Substituted pyrrole derivatives as hmg-coa reductase inhibitors Substituted pyrrole derivatives as hmg-coa reductase inhibitors

A - Human Necessities

61

K

A61K 31/4025 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07D 401/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2527731

The present invention relates to substituted pyrrole derivatives of Formula (I), wherein (Y), with the proviso that one of R2, R4 and R5 is a heterocycle and with the further provision that if R2 is not a heterocycle then either R4 or R5 alone is not unsubstituted pyridyl, which can be used as 3-hydroxy-3- methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.

La présente invention se rapporte à des dérivés de pyrrole substitués selon la Formule (I), dans laquelle (Y) représente (II) ou (III), à condition qu'un élément parmi R¿2?, R¿4? et R¿5? soit un hétérocycle et que, si R¿2? n'est pas un hétérocycle, R¿4? ou R¿5? ne peut pas représenter seul un pyridyle non substitué; pouvant être utilisés comme inhibiteurs de 3-hydroxy-3-méthylglutaryl-coenzyme A (HMG-CoA) réductase. Les composés décrits peuvent agir en tant qu'hypocholestérolémiants et peuvent être utilisés pour traiter des maladies liées au cholestérol ainsi que les symptômes associés. Les procédés de préparation des composés divulgués sont également décrits, ainsi que des compositions pharmaceutiques contenant lesdits composés et des méthodes de traitement de maladies liées au cholestérol et des symptômes associés.

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