Inhibitors of integrin .alpha.v.beta.6

Details Inhibitors of integrin .alpha.v.beta.6 Inhibitors of integrin .alpha.v.beta.6

C - Chemistry, Metallurgy

07

C

C07C 237/04 (2006.01) A61K 31/165 (2006.01) A61K 31/435 (2006.01) C07D 213/74 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2440644

Novel biphenyl derivatives of the general formula (I) in which R1, R1', R1", R2, R2', R3 and n are as defined in Claim 1, their stereoisomers and their physiologically acceptable salts or solvates are novel integrin inhibitors which preferentially inhibit the .alpha.v.beta.6 integrin receptor. The novel compounds can be used, in particular, as medicaments.

Cette invention se rapporte à de nouveaux dérivés du biphényle représentés par la formule générale (I) dans laquelle R?1¿, R?1'¿, R?1''¿, R?2¿, R?2'¿, R?3¿ et n sont tels que définis dans la revendication 1, leurs stéréoisomères et leurs sels ou solvants physiologiquement acceptables étant de nouveaux inhibiteurs de l'intégrine qui inhibent de préférence le récepteur de l'intégrine .alpha.¿v?.beta.¿6?. Ces nouveaux composés peuvent être utilisés, en particulier, comme médicaments.

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