Use of sibutramine analogues to prevent the development of...

Details Use of sibutramine analogues to prevent the development of... Use of sibutramine analogues to prevent the development of...

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 31/137 (2006.01)

Patent

CA 2266401

A compound of formula (I) or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example N,N-dimethyl-1-[1-{4-chlorophenyl)cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used for reducing Insulin resistance in humans in whom Impaired Glucose Tolerance and Non-Insulin Dependent Diabetes Mellitus have not presented.

Cette invention porte sur un composé de la formule (I), ou un sel pharmaceutiquement acceptable dudit composé, dans laquelle R1 et R2 sont, indépendamment, H ou méthyle (par exemple, un chloryhdrate de N,N-diméthyl-1-[1-(4-chlorophényl)cyclobutyl]-3-méthylbutylamine, éventuellement sous la forme de son monohydrate). Ledit composé est utilisé pour diminuer la résistance insulinique chez les sujets chez qui l'intolérance au glucose et le diabète sucré non insulino-dépendant ne sont pas constatés.

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