C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/38 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 31/20 (2006.01) C07H 21/02 (2006.01)
Patent
CA 2514912
The invention relates to methods and compositions that inhibit viral replication, e.g., CMV replication, within a host or host cell. Methods and compositions of the invention utilize RNA interference to block the translation of mRNA into proteins which are important or essential to viral replication. The method and compositions can be used to study CMV infection in in vitro cell culture and to treat CMV infection in non-human primates and human subjects.
L'invention concerne des procédés et des compositions qui inhibent la réplication virale, par exemple celle du CMV, à l'intérieur d'un hôte ou d'une cellule hôte. Les procédés et les compositions selon l'invention utilisent l'interférence ARN pour bloquer la traduction d'ARNm dans des protéines qui sont importantes ou essentielles pour la réplication virale. Les procédés et compositions peuvent être utilisés pour étudier l'infection du CMV dans une culture cellulaire in vitro et pour traiter cette infection chez des primates non humains et des patients humains.
Borden Ladner Gervais Llp
University Of Massachusetts
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