Stabilized preparations for use in nebulizers

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/72 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 9/16 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2304973

Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a stabilized colloidal system which may comprise a fluorochemical component. In particularly preferred embodiments, the stabilized dispersions comprises perforated microstructures dispersed in a fluorochemical suspension medium. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a nebulizer.

La présente invention concerne des dispersions stabilisées permettant de délivrer un agent bioactif dans l'appareil respiratoire d'un patient. Les dispersions comprennent, de préférence, un système colloïdal stabilisé pouvant renfermer un composé fluoré. Dans des modes de réalisation préférés, les dispersions stabilisées comprennent des microstructures perforées dispersées dans un milieu de suspension de composé fluoré. Etant donné que les variations de densité entre les particules en suspension et le milieu de suspension sont minimisées et que les forces d'attraction entre les microstructures sont atténuées, les dispersions de la présente invention sont particulièrement résistantes à la dégradation, par exemple par décantation ou floculation. Dans des modes de réalisation préférés, les dispersions stabilisées peuvent être administrées aux poumons d'un patient à l'aide d'un nébuliseur.

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