Semisynthetic ganglioside analogues

Details Semisynthetic ganglioside analogues Semisynthetic ganglioside analogues

C - Chemistry, Metallurgy

07

H

195/140, 167/199

C07H 5/04 (2006.01) C07H 13/04 (2006.01) C07H 15/10 (2006.01) C12P 19/26 (2006.01)

Patent

CA 2022138

Abstract of the Disclosure N-acyl-N,N'-dilysogangliosides, wherein the acyl groups are derived from unsubstituted aliphatic acids having from 1 to 11 carbon atoms, and N'-acyl-N,N'- dilysogangliosides and N,N'-di-acyl-N,N'- dilysogangliosides, in which the acyl groups are derived from unsubstituted aliphatic acids having from 1 to 24 carbon atoms (with the exception of certain acetyl and diacetyl derivatives). The compounds of the invention exhibit an inhibiting action on protein kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system. Pharmaceutical compositions and therapeutic utilities for the lysoganglioside derivatives are also disclosed.

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