C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61P 37/04 (2006.01) C07K 1/10 (2006.01)
Patent
CA 2613040
The invention relates to a method for the preparation of a stabilized cross- linked oligomer of amyloid beta using a near-zero length bifunctional cross- linking agent for use as an immunogen for the generation of antibodies for the treatment of Alzheimer~s Disease and other conditions related to abnormal amyloid beta aggregation. A preferred bifunctional cross-linking agent is 1,5- difluoro-2,4-dinitrobenzene (DFDNB).
L'invention concerne un procédé de préparation d'un oligomère réticulé stabilisé de peptides bêta-amyloïdes qui utilise un agent de réticulation bifonctionnel de longueur quasi nulle, cet oligomère étant utile comme immunogène pour la production d'anticorps dans le traitement de la maladie d'Alzheimer et d'autres états pathologiques liés à l'agrégation anormale de peptides bêta-amyloïdes. L'agent de réticulation bifonctionnel préféré est le 1,5-difluoro-2,4-dinitrobenzène (DFDNB).
Grimm Karen M.
Joyce Joseph G.
Liang Xiaoping
Nawrocki Denise
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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