Model of transmissible spongiform encephalopathic (tse) disease

Details Model of transmissible spongiform encephalopathic (tse) disease Model of transmissible spongiform encephalopathic (tse) disease

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2438762

The invention relates to the mechanism of transmission of spongiform encephalopathies. The invention proposes simple diagnostic tests for animals that are infected with transmissible spongiform encephalopathic (TSE) disease. The test comprises testing an animal for the presence of mutant non-viral retroelement nucleic acid molecules, wherein the presence of said mutant retroelement nucleic acid molecules is indicative of infection. The invention also proposes methods for the treatment of TSE disease by administering to an animal a therapeutically-effective amount of a compound that is effective to counteract the effect of a non-viral mutant retroelement nucleic acid molecule in inducing TSE disease.

L'invention concerne le mécanisme de transmission des encéphalopathies spongiformes. L'invention décrit des tests diagnostiques simples pour des animaux qui sont infectés par une encéphalopathie spongiforme transmissible (EST). Ces tests sont effectués sur un animal afin de détecter la présence de molécules d'acide nucléique non virales mutantes de rétroélément, laquelle présence indique une infection. L'invention concerne également des méthodes de traitement de l'encéphalopathie spongiforme transmissible qui consistent à administrer à un animal une quantité efficace du point de vue thérapeutique d'un composé efficace pour contrer l'effet que provoque une molécule d'acide nucléique non virale mutante de rétroélément dans l'induction de l'encéphalopathie spongiforme transmissible.

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