N-linked ureas and carbamates of heterocyclic thioesters

Details N-linked ureas and carbamates of heterocyclic thioesters N-linked ureas and carbamates of heterocyclic thioesters

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 211/60 (2006.01) C07D 223/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2239781

This invention relates to neurotrophic low molecular weight, small molecule N-linked ureas and carbamates of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.

L'invention concerne des petites molécules d'urées liées à N, de faible poids moléculaire et neurotrophiques et des carbamates de thioesters hétérocycliques ayant une affinité pour les immunophilines de type FKBP et leur utilisation comme inhibiteurs de l'activité enzymatique associée aux protéines immunophilines, en particulier celle de la peptidyl-propyl isomérase, ou rotamase.

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