Multifunctional ligand system for cell-specific transfer of...

Details Multifunctional ligand system for cell-specific transfer of... Multifunctional ligand system for cell-specific transfer of...

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 16/28 (2006.01) C07K 16/44 (2006.01) C12N 9/24 (2006.01)

Patent

CA 2217159

The invention relates to a multifunctional ligand system that is not immunogenic and that carries out cell-specific transfer of nucleotide sequences. The system comprises at least one target cell-specific ligand, at least one linker and at least one gene construct-specific ligand, with the gene construct-specific ligand advantageously comprising an antibody, or a part thereof, which binds directly or indirectly to the gene construct. The invention also relates to ligand systems for preparing a pharmaceutical or a vaccine for the treatment or prevention of a disease of the skin, of the mucous membranes, of the nervous system, of the internal organs, of blood coagulation, of the hemopoietic system, of the immune system, of the musculature, of the sustentacular tissue or of the joints.

L'invention concerne un système de ligands multifonctionnels qui n'est pas immunogène et qui effectue un transfert de séquences nucléotidiques qui est spécifique de la cellule. Le système comprend au moins un ligand spécifique de la cellule cible, au moins une séquence de liaison et au moins un ligand spécifique du construit génique, le ligand spécifique du construit génique comprenant avantageusement un anticorps, ou une partie d'anticorps, qui se lie directement ou indirectement au construit génique. L'invention concerne également des systèmes de ligands pour préparer un produit pharmaceutique ou un vaccin destinés au traitement ou à la prévention des états ou affections touchant la peau, les membranes muqueuses, le système nerveux, les organes internes, la coagulation du sang, le système hématopoïétique, le système immunitaire, les muscles, le tissu constitué des fibres de Müller ou les articulations.

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