Inducible lymphoid specific protein tyrosine phosphatase

Details Inducible lymphoid specific protein tyrosine phosphatase Inducible lymphoid specific protein tyrosine phosphatase

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C07H 21/00 (2006.01) C12N 9/16 (2006.01)

Patent

CA 2086377

Abstract of the Disclosure Tyrosine phosphorylation and dephosphorylating event have been shown to be central to the process of growth regulation and signal transduction. The invention is the identification of a new gene with a tyrosine phosphatase domain (EC 3.1.3.48) which is expressed exclusively in thymus and spleen. A cDNA of 2760 bp encodes a 339 amino acid, intracellular, single domain tyrosine phosphatase. When expressed as a glutathionine- S-transferase fusion protein, efficient lysis of p-nitrophenyl phosphate is noted, indicating in vitro enzymatic activity of the cloned gene product. Normal mouse lymphocytes increase mRNA expression 10-15 fold upon stimulation with phytohemaglutinin, concanavalian A, lipopolysaccharide or anti-CD3 monoclonal antibody. This new hematopoietic tyrosine phosphatase, (HePTPase), may play a role in the regulation of T and B lymphocyte developement and signal transduction.

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