Oral dtpa for radionuclide chelation

Details Oral dtpa for radionuclide chelation Oral dtpa for radionuclide chelation

A - Human Necessities

61

K

A61K 31/13 (2006.01) A61K 49/20 (2006.01) A61P 39/04 (2006.01)

Patent

CA 2637215

A composition for oral radionuclide chelation therapy comprises a DTPA chelate selected from Zn-DTPA and Ca-DTPA and a permeation enhancer that preferentially increases jejunal uptake of the DTPA chelate. The composition has a DTPA chelate bioavailability of at least 10% of the chelate when orally administered to a mammal.

La présente invention concerne une composition destinée à une thérapie orale par chélation de radionucléides qui contient un chélate de DTPA choisi parmi le Zn-DTPA et le Ca-DTPA ainsi qu'un adjuvant de perméation qui augmente préférentiellement l'assimilation jéjunale du chélate de DTPA. La composition présente une biodisponibilité du chélate de DTPA d'au moins 10 % de l'élément chélaté lorsqu'elle est administrée par voie orale à un mammifère.

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