Amelioration of drug-induced toxicity

Details Amelioration of drug-induced toxicity Amelioration of drug-induced toxicity

A - Human Necessities

61

K

A61K 39/00 (2006.01)

Patent

CA 2572684

Kidney toxicity which is induced by cisplatin and other therapeutic and diagnostic agents, limits the effectiveness of the therapy or diagnosis. Modulation or depletion of T cells ameliorates the toxicity, permitting the use of cisplatin at levels and for durations which treat cancers more effectively. Modulation and depletion can be accomplished using antibodies for T cell surface antigens as well as using other molecules which effectively antagonize or down-regulate the cytokines and/or chemokines which T cells elaborate.

La toxicité rénale induite par le cisplatine et d'autres agents thérapeutiques et diagnostiques limite l'efficacité de la thérapie ou du diagnostic. Une modulation ou déplétion des lymphocytes T améliore la toxicité, permettant d'utiliser le cisplatine à des taux et pendant des durées traitant les cancers de manière plus efficace. Une modulation et une déplétion peuvent être obtenues au moyen d'anticorps destinés aux antigènes de surface des lymphocytes T, ainsi qu'au moyen d'autres molécules antagonisant ou régulant négativement les cytokines et/ou chimiokines élaborant des lymphocytes T.

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